adipose- derived stem cells as a tool for dental implant osseointegration: an experimental study in the dog

نویسندگان

eriberto bressan department of neurosciences, university of padua, padua, italy.

daniele botticelli faculty of dentistry, university of medical science, la habana, cuba.

stefano sivolella department of neurosciences, university of padua, padua, italy.

franco bengazi faculty of dentistry, university of medical science, la habana, cuba.

چکیده

the biological interaction between the jaw bones and dental implant is fundamental for the long-term success of dental implant placement. nevertheless, the insufficient bone volume remains a major clinical problem, especially in case of immediate dental implant. using a canine model, the present study proves the regenerative potential of adipose- derived stem cells (adscs) to repair peri-implant bone defects occurring in immediate dental implant placement. in six labradors, all mandibular premolars and the first molars were extracted bilaterally and three months later dental implants were installed with a marginal gap. the marginal defects were filled with hydroxyapatite (ha)-based scaffolds previously seeded with adscs. after one month of healing, specimens were prepared for histological and histomorphometric evaluations. histological analyses of ground sections show that adscs significantly increase bone regeneration. several new vessels, osteoblasts and new bone matrix were detected. by contrast, no inflammatory cells have been revealed. adscs could be used to accelerate bone healing in peri- implant defects in case of immediate dental implant placement.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Adipose- Derived Stem Cells as a Tool for Dental Implant Osseointegration: an Experimental Study in the Dog

The biological interaction between the jaw bones and dental implant is fundamental for the long-term success of dental implant placement. Nevertheless, the insufficient bone volume remains a major clinical problem, especially in case of immediate dental implant. Using a canine model, the present study proves the regenerative potential of adipose- derived stem cells (ADSCs) to repair peri-implan...

متن کامل

Adipose-Derived Stem Cells as a Tool for Dental Implant Osseointegration: an Experimental Study in the Dog

The biological interaction between the jaw bones and dental implant is fundamental for the long-term success of dental implant placement. Nevertheless, the insufficient bone volume remains a major clinical problem, especially in case of immediate dental implant. Using a canine model, the present study proves the regenerative potential of adipose- derived stem cells (ADSCs) to repair peri-implan...

متن کامل

An animal model study for bone repair with encapsulated differentiated osteoblasts from adipose-derived stem cells in alginate

Objective(s): Adipose derived stem cells (ADSCs) can be engineered to express bone specific markers. The aim of this study is to evaluate repairing tibia in animal model with differentiated osteoblasts from autologous ADSCs in alginate scaffold. Materials and Methods: In this study, 6 canine’s ADSCs were encapsulated in alginate and differentiated into osteoblasts. Alkaline phosphatase assay (A...

متن کامل

The Effect of Simplifying Dental Implant Drilling Sequence on Osseointegration: An Experimental Study in Dogs

Objectives. To test the hypothesis that there would be no differences in osseointegration by reducing the number of drills for site preparation relative to conventional drilling sequence. Methods. Seventy-two implants were bilaterally placed in the tibia of 18 beagle dogs and remained for 1, 3, and 5 weeks. Thirty-six implants were 3.75 mm in diameter and the other 36 were 4.2 mm. Half of the i...

متن کامل

adipose derived stem cells for treatment of mandibular bone defects: an autologous study in dogs

background: the aim of this research was to evaluate the effect of adipose derived stem cells on bone repair in through and through mandibular bone defects of canine. materials and methods: in this prospective comparative study, adipose-derived stem cells were isolated from subcutaneous fat of lateral thoracic area of 4 dogs. the isolated cells were cultured and expanded through 3 passages. the...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
international journal of molecular and cellular medicine

جلد ۴، شماره ۴، صفحات ۱۹۷-۲۰۸

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023